Need genetic info of humans w/ red hair, brown eyes, and somewhat freckled yet tan-able skin?

Grant

I'm a man with red hair(specifically orange-brown hair), medium brown eyes, with skin that can tan but also lightly freckles.

I have a mostly constant skin tone with about 10% freckling of different shades. Most of the freckles on my skin are evenly distributed and light to medium brown in pigment, but the smaller percentage of the freckles on my skin have a dark brown pigment, are more randomly distributed, and are somewhat bigger in width than the lighter ones making them more noticeable. When I was a kid my skin wouldn't get sun burned like other red haired people but it would have to have more frequent exposure to the sun than other white people who could tan to be as tan as them. I'm not saying I tried to be tan in comparison to other people then I was just outside and exposed to the sun for at least 3 - 4 hours, on average. I only started to think about this a couple years ago. This is just retrospective analysis. Back then, though, I wouldn't get freckles. When I transitioned into a teenager my lifestyle reduced my exposure the sun to almost probably 1 hour a day and I was paler. I'm 25, the past 10 years my skin started to produce freckles much easier. Is this because of years of reduced sunlight somehow making the dynamics of my skin change when hit with adequate amounts of sunlight? I just want data on this genetic make up if anyone can give any?

Answer
The melanocortin-1-receptor gene (MC1-r) on the surface of melanocyte cells is important in converting the red pigment phomelanin to brown pigment melanin. If you are European and have red hair you probably have an allele of MC1-R that does not convert all the phomelanin. The ratio of red to brown pigment determines hair and skin coloration.

The gene SLC24A5 expresses the protein that determines the melanin density of the skin so different alleles of this gene impact skin color. The A variant allele is found in humans with less skin melanin.

The eye color genes EYCL-1, EYCL-2 & EYCL-3 determine melanin's local distribution in the iris and its background skin so influence eye color from this pigment.

Certain alleles of MC1-r are linked to fair skin and freckles.
http://ghr.nlm.nih.gov/gene/MC1R
MC1R "Freckles" gene study
http://forums.skadi.net/showthread.php?t=73501

SLC24A5 research began in zebra fish that carry the A allele
http://evolution.berkeley.edu/evolibrary/news/060201_zebrafish
http://www.sciam.com/article.cfm?articleID=0002E7CA-F27B-13A1-AFAA83414B7FFE9F&sc=I100322
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCY-4KF780Y-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c39582b9f961afc107a5a51137475ac5


SLC24A5, SLC45A2, TYRP1 and DCT genes express proteins that alter the quality of the melanin produced or impact the skin pigmentation levels.
http://hmg.oxfordjournals.org/content/18/R1/R9.full

How can I enhance my Natural hair colour without dye?

Yippee

I have a sort of light red-ish brown hair colour (it's hard to explain) but I'd like it to be more on the red side. How can I enhance the red in my hair without using permanent dye. I've already tried the "red" shampoos and they don't have enough impact. what else can I use?

Answer
hello there,
in here you can learn more about red hair:

"The pigment pheomelanin gives red hair its distinctive color. Red hair has far more pheomelanin than other hair colors, but far less of the dark pigment eumelanin. Auburn hair has both high levels of pheomelanin and eumelanin.

The genetics of red hair, discovered in 1997, appears to be associated with the melanocortin-1 receptor (MC1R), which is found on chromosome 16. Red hair is associated with fair skin color due to low concentrations of eumelanin. This lower melanin-concentration has the advantage that a sufficient concentration of important Vitamin D can be produced under low light conditions. However, when the UV-radiation is strong (like in the regions close to the equator) the lower concentration of melanin leads to several medical disadvantages - one of them is the higher rate of skin cancer.

The MC1R recessive variant gene, which gives people red hair and fair skin, is also associated with freckles, though it is not uncommon to see a redhead without freckles. Eighty percent of redheads have an MC1R gene variant,[13] and the prevalence of these alleles is highest in Scotland and Ireland. The alleles that code for red hair occur close to the alleles that impact skin color, so it seems that the phenotypic expression for lighter skin and red hair are interrelated.

Red hair can originate from several different changes on the MC1R-gene. If one of these changes is present on both chromosomes then the respective individual is likely to have red hair. This type of inheritance is described as an autosomal recessive mode of inheritance. Even if both parents may not have red hair themselves they both can be carriers for the gene and have a redheaded child. (red hair genetics)." in http://en.wikipedia.org/wiki/Red_hair

and... http://www.telegraph.co.uk/connected/main.jhtml?xml=/connected/2002/10/04/ecfhair04.xml&sSheet=/connected/2002/10/04/ixconn.html

Just keep your hair healthy :)

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